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Product name : VX661
Item : CR1810
Price : 200mg, $750;500mg, $1290; 1g, $1990; 2g, $2995
contact : Send inquiry to: info@acesobio.com
CAS : 1152311-62-0
Molecular Weight : 520.5
Formula : C₂₆H₂₇F₃N₂O₆
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
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 Chemical Information
M.Wt 520.5 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C26H27F3N2O6
CAS No 1152311-62-0


Biological Activity of VX-661


VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.
IC50 value:
Target: F508del CFTR
VX-661, known as a CTFR corrector, allows F508del mutant channels to escape degradation and transit to the cell membrane.


Clinical Information of VX-661


[1]. Study of VX-661 Alone and in Combination With VX-770 in Subjects Homozygous to the F508del-CFTR Mutation
The purpose of this study is to evaluate the safety, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) effects of VX-661 alone and when coadministered with VX-770 in subjects with CF who are homozygous for the F508del-CFTR mutation.

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