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Product name : VX661
Item : CR1810
Price : 100mg, $595; 200mg, $1095;
contact : Send inquiry to: info@acesobio.com
Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 1152311-62-0
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Details:
 Chemical Information
M.Wt 520.5 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C26H27F3N2O6
CAS No 1152311-62-0
Solubility

DMSO



Biological Activity of VX-661

 

VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.
IC50 value:
Target: F508del CFTR
VX-661, known as a CTFR corrector, allows F508del mutant channels to escape degradation and transit to the cell membrane.

 

Clinical Information of VX-661

MORE

[1]. Study of VX-661 Alone and in Combination With VX-770 in Subjects Homozygous to the F508del-CFTR Mutation
Abstract
The purpose of this study is to evaluate the safety, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) effects of VX-661 alone and when coadministered with VX-770 in subjects with CF who are homozygous for the F508del-CFTR mutation.


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