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Product name : TAK 700
Item : cc589
Price : 10mg, $325; 50mg, $895; 100mg, $1695; 200mg,$2475
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
TAK-700 (Orteronel) is a potent and highly selective rat and human 17,20-lyase inhibitor with IC50 of 54 nM and 38 nM, respectively. TAK700 binds to and inhibits the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells. The cytochrome P450 enzyme CYP17A1 (P450C17), localized to the endoplasmic reticulum (ER), exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces steroidal hormones, such as progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens.   [1][2]
 
Reference:
[1] J Steroid Biochem. Mol. Biol. 2012, 129, 115-128.
[2] Bioorg. Med. Chem. 2011, 19, 6383-6399.
 
 
Chemical Information
Molecular Weight (WM):
307.35
Formula:
C18H17N3O2
CAS No:
566939-85-3
Purity:
≥ 98%
Synonyms:
TAK 700
 
DMSO ≥ 62 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 62 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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