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Product name : Mdivi 1
Item : CR1787
Price : 500mg, $745; 1g, $1285
contact : Send inquiry to: info@acesobio.com
Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 338967-87-6
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Details:
 Chemical Information
M.Wt 353.22 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C15H10Cl2N2O2S
CAS No 338967-87-6
Solubility

DMSO > 20 mg/ml



Biological Activity of Mdivi-1

 

Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1).
IC50 value:
Target: mitochondrial division Dynamin I; DRP1
in vitro: In cells, mdivi-1 retards apoptosis by inhibiting mitochondrial outer membrane permeabilization. In vitro, mdivi-1 potently blocks Bid-activated Bax/Bak-dependent cytochrome c release from mitochondria [1]. Mdivi-1 prevents mitochondria division and Bax-mediated mitochondrial outer membrane permeabilization during apoptosis [2].
in vivo: C57BL/6 mice received injections of mdivi-1 (50 mg/kg) or vehicle, and then transient retinal ischemia was induced by acute IOP elevation. Mdivi-1 treatment blocked apoptotic cell death in ischemic retina, and significantly increased RGC survival at 2 weeks after ischemia. Mdivi-1 treatment did not change this increase of Drp1 protein expression but significantly decreased GFAP protein expression [3]. mdivi-1 (1.2mg/kg) significantly reduced cerebral damage induced by ischemia/reperfusion [4].

 

[1]. Cassidy-Stone A, et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008 Feb;14(2):193-204.
[2]. Tanaka A, et al. A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol Cell. 2008 Feb 29;29(4):409-10.
[3]. Park SW, et al. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci. 2011 Apr 27;52(5):2837-43.
[4]. Zhang N, et al. A selective inhibitor of Drp1, mdivi-1, acts against cerebral ischemia/reperfusion injury via an anti-apoptotic pathway in rats. Neurosci Lett. 2013 Feb 22;535:104-9.


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