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Product name : Vernakalant (RSD 1235)
Item : cc-484
Price : 10mg, $325; 50mg, $875; 100mg, $1695; 200mg,$2175
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
Vernakalant (RSD 1235) blocks atrial potassium channels, thereby prolonging repolarization. It differs from typical class III agents by blocking a certain type of potassium channel, the cardiac transient outward potassium current, with increased potency as the heart rate increases. This means that it is more effective at high heart rates, while other class III agents tend to lose effectiveness under these circumstances. It also slightly blocks the hERG potassium channel, leading to a prolonged QT interval. This may theoretically increase the risk of ventricular tachycardia, though this does not seem to be clinically relevant.[1][2]
 
Reference:
[1] Nature Rev. Drug Disc. 2010, 9, 915-916.
[2] J Cardiovas. Electrophysiol. 2005, 16, 1227-1238.
 
 
Chemical Information
Molecular Weight (WM):
349.47
Formula:
C20H31NO4
CAS No:
794466-70-9
Purity:
≥ 98%
Synonyms:
SRD1235, SRD-1235
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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