GW 791343

GW-791343 hydrochloride is a non-competitive P2X7 allosteric modulator. GW791343 exhibits species-specific activity; acts as a negative allosteric mod...

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Prucalopride

Prucalopride, a first in class dihydrobenzofurancarboxamide, is a selective, high affinity serotonin (5-HT4) receptor agonist with enterokinetic activ...

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Lurasidone (SM 13496)

Lurasidone (SM-13496) acts as an antagonist of dopamine D2, serotonin 5-HT7, 5-HT2A, 5-HT1A receptors and alpha2C adrenoceptor with Ki of 1.0, 0.5, 0....

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Ticagrelor (AZD 6140)

Ticagrelor (AR-C 126532XX, AZD-6140) blocks adenosine diphosphate (ADP) receptors of subtype P2Y12. In contrast to the other antiplatelet drugs, ticag...

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Iguratimod (T 614)

Iguratimod (T-614) is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity. Iguratimod is ...

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Palonosetron

Palonosetron competitively blocks the action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal afferents in the chemorecep...

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LY 2811376

LY 2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals. [1][2] ...

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Panadiplon

Panadiplon (U-78875) is an anxiolytic drug with a novel chemical structure that is not closely related to other drugs of this type. Panadiplon acts as...

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Duloxetine (Cymbalta)

Duloxetine (sold under the brand names Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela) is a serotonin-norepinephrine reuptake inhibitor (SNRI). It is ...

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Bepotastine besilate

Bepotastine Beslilate (Bepreve) is a histamine H1 receptor anatagonist. Bepotastine Beslilate (Bepreve)also suppresses some allergic inflammatory proc...

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MK 0974 (Telcagepant)

MK-0974 (telcagepant) acts as a calcitonin gene-related peptide receptor (CRLR) antagonist and blocks this peptide. It is believed to constrict dilate...

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Celecoxib (Celebrex)

Celecoxib (Celebra; Celebrex; SC 58635) is a highly selective COX-2 inhibitor and primarily inhibits this isoform of cyclooxygenase (and thus causes i...

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Tolterodine tartrate (Deltol LA)

Tolterodine tartrate (Detrol LA) is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist. High affinity muscarinic rece...

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A 740003

A-740003 is a novel competitive antagonist of P2X7 receptors (IC50 values = 40 nM for human and 18 nM for rat) as measured by agonist-stimulated...

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