Vicriviroc

Vicriviroc Malate is a second generation orally active CCR5 antagonist, which is also a potent inhibitor of HIV-1 entry into target cells, with a mean...

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Raltegravir (MK 0518)

Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM, respectivly. Raltegravir (MK0518) tar...

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INCB 3284

INCB-3284 dimesylate is a potent, selective hCCR2 antagonist that exhibits potenct antagonism against monocyte chemoattractant molecule binding to hCC...

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INCB 8761 (PF 4136309)

INCB-8761 (PF-4136309) exhibited potent CCR2 antagonistic activity, high selectivity, weak hERG activity, and an excellent in vitro and in vivo ADMET ...

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MK 0812

MK-0812 is a small molecule CCR2 antagonist. Neutrophils and monocytes are abundantly represented in the synovial fluid and tissue in rheumatoid arthr...

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MK 2048

MK-2048 is a second generation integrase inhibitor for integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively. MK2048 inhibits subtyp...

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Maraviroc (UK-427857)

Maraviroc (Selzentry, Celsentri) is an entry inhibitor. Specifically, maraviroc is a negative allosteric modulator of the CCR5 receptor, which is foun...

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Dolutegravir (S/SGSK1349572)

Dolutegravir (GSK-1349572) is a novel potent integrase inhibitor with an IC50 of 2.7 nM in vitro. S/GSK-1349572 (GSK1349572) is a compound for the tre...

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Elvitegravir (GS-9137)

Elvitegravir (GS-9137) is a human immunodeficiency virus integrase inhibitor to HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1....

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BMS 707035

BMS-707035 is a potent, specific, and reversible HIV-I integrase (IN) inhibitor that blocks HIV IN strand transfer activity with IC50 of 15 nM. The bi...

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