WYE-125132/WYE125132/WYE 125132/WYE-132/WYE132/WYE 132/1144068-46-1/acesobio supply

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Products > PI3K/Akt/mTOR > mTOR > WYE 125132 (WYE 132)

Product name : WYE 125132 (WYE 132)

Item : cc15

Price : 200mg, $1250;500mg, $2150; 1g $3050; 2g, $4450

contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.

CAS : 1144068-46-1

Molecular Weight : 519.6

Formula : C₂₇H₃₃N₇O₄

Storage : at -20°C

Additional information : We offer significant discount for larger quantity order

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Details:

WYE-125132 (WYE-132), is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC₅₀: 0.19 ± 0.07 nmol/L; >5,000-fold selective versus PI3Ks). WYE-132 inhibited mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo. Importantly, consistent with genetic ablation of mTORC2, WYE-132 targeted P-AKT(S473) and AKT function without significantly reducing the steady-state level of the PI3K/PDK1 activity biomarker P-AKT(T308), highlighting a prominent and direct regulation of AKT by mTORC2 in cancer cells. ^[1][2]

Reference:

[1] Cancer Res. 2010, 70, 621.

[2] J Biol. Chem. 2010, 285, 15380-15392.

Chemical Information

Molecular Weight (WM):	519.60
Formula:	C₂₇H₃₃N₇O₄
CAS No:	1144068-46-1
Purity:	≥ 98%
Synonyms:	WYE125132, WYE-125132,WYE-132
	DMSO ≥ 104 mg/mL
Solubility: (R.T.: 25℃):	Water < 1 mg/mL
	Ethanol < 1 mg/mL
	2 years -20℃ Powder
Stability:	2 weeks -4℃ in DMSO
	2 months -80℃ in DMSO