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Products > PI3K/Akt/mTOR > mTOR > WYE 125132 (WYE 132)
Product name : WYE 125132 (WYE 132)
Item : cc15
Price : 10mg, $295; 50mg, $755; 100mg, $1295; 200mg, $1995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
WYE-125132 (WYE-132), is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC50: 0.19 ± 0.07 nmol/L; >5,000-fold selective versus PI3Ks). WYE-132 inhibited mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo. Importantly, consistent with genetic ablation of mTORC2, WYE-132 targeted P-AKT(S473) and AKT function without significantly reducing the steady-state level of the PI3K/PDK1 activity biomarker P-AKT(T308), highlighting a prominent and direct regulation of AKT by mTORC2 in cancer cells.  [1][2]
 
Reference:
[1] Cancer Res. 2010, 70, 621.
[2] J Biol. Chem. 2010, 285, 15380-15392.
 
 
Chemical Information
Molecular Weight (WM):
519.60
Formula:
C27H33N7O4
CAS No:
1144068-46-1
Purity:
≥ 98%
Synonyms:
WYE125132, WYE-125132,WYE-132
 
DMSO ≥ 104 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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