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Product name : WYE 687
Item : cc613
Price : 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1062161-90-3
Molecular Weight : 528.61
Formula : C₂₈H₃₂N₈O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
WYE-687 is a potent ATP-competitive mTOR inhibitor with an IC50 of 7 nM. WYE687 is well reported that the mammalian target of rapamycin (mTOR) is centrally involved in cell growth, metabolism, and angiogenesis. Significantly, the pyrazolopyrimidines were selective for mTOR over PI3Kα (>100-fold) and PI3Kγ (>500-fold) and were poorly active in a panel of 24 protein kinases. Unlike the rapalogs, WYE 687 acutely blocked mTORC2-dependent phosphorylation of AKT in vitro and in vivo.  [1]
 
Reference:
[1] Cancer Res. 2009, 69, 6232-6240.
 
 
Chemical Information
Molecular Weight (WM):
528.61
Formula:
C28H32N8O3
CAS No:
1062161-90-3, 1198178-23-2 (HCl)
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 1 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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