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Product name : MK 0752
Item : cc14
Price : 10mg, $295; 50mg, $755; 100mg, $1295; 200mg, $1995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM in human SH-SY5Y cells. MK0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. The Notch signaling pathway plays an important role in cell-fate determination, cell survival, and cell proliferation.  [1][2]
 
Reference:
[1] J Neurosci. 2010, 30, 6743-6750.
[2] J Clin. Oncol. 2011, 29, 3529-3524.
 
 
Chemical Information
Molecular Weight (WM):
442.90
Formula:
C21H21ClF2O4S
CAS No:
471905-41-6
Purity:
≥ 98%
Synonyms:
MK 0752
 
DMSO ≥ 89 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 45 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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