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Product name : Rebastinib (DCC 2036)
Item : cc606
Price : 10mg, $225; 50mg, $695; 100mg, $1195; 200mg, $1895
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
DCC-2036 is a conformational control inhibitor of Abl1 and T315I Abl1 with IC50 of 0.8 nM and 4 nM, respectively. DCC2036 binds to and inhibits the Bcr-Abl fusion oncoprotein by changing the conformation of the folded protein to disallow ligand-dependent and ligand-independent activation; in addition, DCC 2036 binds to and inhibits Src family kinases LYN, HCK and FGR and the receptor tyrosine kinases TIE-2 and VEGFR-2. [1][2]
 
Reference:
[1] Blood 2011, 118, 5250-5254.
[2] Cancer Res. 2011, 71, 3189-3195.
 
 
Chemical Information
Molecular Weight (WM):
553.59
Formula:
C30H28FN7O3
CAS No:
1020172-07-9, 1020172-08-0 (2HCl), 1033893-29-6 (4-methylbenzenesulfonate)
Purity:
≥ 98%
Synonyms:
Rebastinib
 
DMSO ≥ 111 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 16 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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