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Product name : INK 128 (MLN 0218)
Item : cc779
Price : 10mg, $225; 50mg, $795; 100mg, $1295; 200mg, $2195
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
INK-128 (MLN-0218) is a potent and selective mTOR inhibitor with IC50 of 1 nM. TORC1/2 inhibitor INK128 binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers. [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2009, 8,
[2] Nature 2012, 485, 55-61.
 
Chemical Information
Molecular Weight (WM):
309.32
Formula:
C15H15N7O
CAS No:
1224844-38-5
Purity:
≥ 98%
Synonyms:
INK128, MLN0128
 
DMSO ≥ 62 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 2 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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