Product name : INK 128 (MLN 0218)
Item : cc779
Price : 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
contact : Send inquiry to: info@acesobio.com
CAS : 1224844-38-5
Molecular Weight : 309.33
Formula : C₁₅H₁₅N₇O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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INK-128 (MLN-0218) is a potent and selective mTOR inhibitor with IC50 of 1 nM. TORC1/2 inhibitor INK128 binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers. [1][2]
Reference:
[1] Mol. Cancer Ther. 2009, 8,
[2] Nature 2012, 485, 55-61.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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