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Product name : Cytochalasin H
Item : C2479
Price : 200mg, $1750;500mg, $2790; 1g, $3890;
contact : Send inquiry to: info@acesobio.com
CAS : 53760-19-3
Molecular Weight : 493.64
Formula : C30H39NO5
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
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Details:
Description of:Cytochalasin H
Cytochalasin H(CAS: 53760-19-3)is used in actin polymerization studies. Cytochalasins are potent mycotoxins which bind to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Used as a tool for cytological research. These fungal toxins are related by their chemical structure characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. In vitro, cytochalasin H exhibits antibacterial, antifungal, nematocidal and antitumor activity.
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin H is a potent inhibitor of actin incorporation into filaments. Like cytochalasin D , it also increases the steady-state diffusion coefficients of filaments, suggesting that it stimulates filament shortening.Cytochalasin H suppresses the production of reactive oxygen species by stimulated human neutrophils, blocks endocytosis of CD59 in lymphocytes, and shows anti-angiogenic activity both in vitro and in vivo.

Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.

REFERENCES

1. Toxicity and plant growth regulator effects of cytochalasin H isolated from Phomopsis sp.: J.M. Wells, et al.;Can. J. Microbiol. 22, 1137 (1976)
2. Structure of a new [11]cytochalasin, cytochalasin H or kodo-cytochalasin-1: M. A. Beno, et al.; JACS 99,4123 (1977)
3. Effect of cytochalasins B & H on isoelectric focusing of chick embryonic neural retina cells: S. Ghaskadbi &L. Mulherkar; Indian J. Exp. Biol. 20, 869 (1982)
4. Effects of cytochalasin H on chick embryo explants cultured in vitro: S. Ghaskadbi, et al. Toxicology 33, 323 (1984)
5. Effects of cytochalasin and phalloidin on actin: J.A. Cooper; J. Cell Biol. 105, 1473 (1987)
6. A new immunosuppressive cytochalasin isolated from a Pestalotia sp.: N. S. Burres, et al.; J. Antibiot. 45,1367 (1992)
7. Effects of cytochalasin H, a potent inhibitor of cytoskeletal reorganization, on platelet function: P. Natajaran,et al.; Platelets, 11, 467 (2000)
8. 1H and 13C NMR assignments of three nitrogen containing compounds from the mangrove endophytic fungus (ZZF08): Y. Tao, et al.; Magn. Reson. Chem. 46, 501 (2008)
9. Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa: S. Xu, et al.; Chem. Biodivers. 6, 739 (2009)
10. Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines: S.M. Stoeger & K.H. Cowan; Cancer Chemother. Pharmacol. 63, 807 (2009)
11. Application of cytochalasin compound cytochalasin H in manufacture of the medicine for resisting Parkinson"s disease: L. Shet, et al.; CN103816149 A20140528 (2014) (Patent)
12. Cytochalasin H, an active anti-angiogenic constituent of the ethanol extract of Gleditsia sinensis Thorns: J. Lee, et al.; Biol. Pharm. Bull. 37, 6 (2014)

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