Mirabegron (YM 178)

Mirabegron (YM-178) is a beta-3 adrenergic agonist. Mirabegron activates the β3 adrenergic receptor in the detrusor muscle in the bladder, which ...

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Fulvestrant (Faslodex)

Fulvestrant (Faslodex) is an estrogen receptor (ER) antagonist with IC50 of 0.094 nM. Fulvestrant is efficacious in the treatment of estrogen-sensitiv...

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GW 9508

GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32. GPR40 and GPR120 are G protein-coupled receptors (GPCR) that are activat...

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Aliskiren

Aliskiren is a direct renin inhibitor with an IC50 of 0.72 nM against renin. Renin is the first enzyme in the renin-angiotensin-aldosterone sys...

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Raloxifene

Raloxifene is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and b...

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Rosuvastatin (Crestor)

Rosuvastatin (Crestor) is a member of the drug class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular ...

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Fadrozole

Fadrozole specifically inhibits aromatase, blocking the aromatization of androstenedione and testosterone into estrone and estradiol, respectively, th...

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GW 4064

GW-4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM).GW4064 displays no activity at other nuclear receptors at conc...

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MBX 2982

MBX-2982 is a potential first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119 (GPR119), a receptor that interacts w...

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Andarine (GRX 007)

Andarine (GTX 007) is an orally active partial agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SA...

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GSK1292263

GSK 1292263 is a novel GPR119 receptor agonist that is currently under development for the treatment of type 2 diabetes. Treatment of male Sprague-Daw...

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TAK 875

TAK 875 is a potent, selective and orally bioavailable GPR40 agonist with an EC50 of 0.072 μM. TAK-875 is a new agent applied in the treatment of t...

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Enzalutamide (MDV3100)

Enzalutamide (MDV3100) is an experimental androgen receptor antagonist drug developed by the pharmaceutical company Medivation for the treatment of ca...

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Galeterone (TOK 001, VN 124)

Galeterone (TOK-001 or VN/124-1) is a drug that being developed by Tokai Pharmaceuticals, Inc. for the treatment of prostate cancer. It is both an and...

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