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BGP-15
Description of:BGP-15(cas:66611-37-8)
BGP-15 is a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin wi...
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Inolitazone (Efatutazone)
Inolitazone (Efatutazone) is an orally bioavailable PAPR-gamma inhibitor with potential antineoplastic activity. Inolitazone binds to and activates pe...
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Atopaxar (E 5555)
Atopaxar (E-5555) is a potent protease-activated receptor (PAR-1) antagonist targeting the G-coupled receptor and modulating thrombin-platelet-endothe...
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AG 14361
AG 14361 is a PARP-1 inhibitor with Ki < 5 nmol/L. AG14361 is at least 1000-fold more potent than the benzamides. The IC50 for AG14361 is 29 nM in ...
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ABT 888 (Veliparib)
Veliparib (ABT 888) is a poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with Kis of 5.2 and 2.9 nM respectively. With no antiproliferative eff...
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Olaparib (AZD2281)
Olaparib (AZD 2281) acts as an inhibitor of the enzyme Poly ADP ribose polymerase (PARP) and is one of the first PARP inhibitors. Patients with BRCA1/...
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Iniparib (BSI-201)
Iniparib (BSI-201) is a potent PARP1 inhibitor with strong anti-neoplastic effect. BSI-201 covalently binds and inhibits PARP-1. When given as a singl...
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Apoptosis
PARP
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