Apoptosis
Telomerase
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Product name : WYE 354
Item : cc506
Price : 200mg, $950;500mg, $1650; 1g $2450; 2g, $3650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1062169-56-5
Molecular Weight : 495.53
Formula : C₂₄H₂₉N₇O₅
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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WYE 354 is a cell-permeable pyrazolopyrimidine compound that acts as a potent and ATP-competitive mTOR inhibitor (IC50 = 5 nM with S6K as the substrate and 100 µM ATP) with much reduced activity against PI 3-Kα or PI 3-Kγ (IC50 = 1.89 and 7.37 µM, respectively) and little or no activity toward 24 other kinases (IC50 >50 µM). WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 µM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth.[1][2]
Reference:
[1] Cancer Res. 2009, 69, 6232-6240.
[2] Mol. Cancer Res. 2012, 10, 821-833.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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