Favorite  |  Set Home
Product name : WYE 354
Item : cc506
Price : 200mg, $950;500mg, $1650; 1g $2450; 2g, $3650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1062169-56-5
Molecular Weight : 495.53
Formula : C₂₄H₂₉N₇O₅
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
WYE 354 is a cell-permeable pyrazolopyrimidine compound that acts as a potent and ATP-competitive mTOR inhibitor (IC50 = 5 nM with S6K as the substrate and 100 µM ATP) with much reduced activity against PI 3-Kα or PI 3-Kγ (IC50 = 1.89 and 7.37 µM, respectively) and little or no activity toward 24 other kinases (IC50 >50 µM). WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 µM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth.[1][2]
 
Reference:
[1] Cancer Res. 2009, 69, 6232-6240.
[2] Mol. Cancer Res. 2012, 10, 821-833.
 
 
Chemical Information
Molecular Weight (WM):
495.53
Formula:
C24H29N7O5
CAS No:
1062169-56-5
Purity:
≥ 98%
Synonyms:
WYE 354, WYE-354
 
DMSO ≥ 99 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

Related Products :
AZD 2014
AZD 2014
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
WYE 687
WYE 687
Price: 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
GDC 0349
GDC 0349
Price: 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
Temsirolimus (Torisel)
Temsirolimus (Torisel)
Price: 200mg, $450;500mg, $850; 1g $1250; 2g, $1850
Everolimus (RAD001)
Everolimus (RAD001)
Price: 200mg, $450;500mg, $850; 1g $1250; 2g, $1850
OSI 027
OSI 027
Price: 200mg, $1250;500mg, $2150; 1g $3050; 2g, $4450
Zotarolimus (ABT 578, A 179578)
Zotarolimus (ABT 578, A 179578)
Price: 200mg, $1750;500mg, $3190;
Compound 401
Compound 401
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590