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Product name : Tivozanib (AV-951)
Item : cc12
Price : 10mg, $145; 50mg, $495; 100mg, $795; 200mg, $995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
AV-951 (Tivozanib, KRN-951) is a potent and selective VEGFR inhibitor to all three VEGF receptors, VEGFR-1, -2 and -3 with IC50 of 0.21 nM, 0.16 nM and 0.24 nM, respectively.AV951 blocks VEGF-dependent activation of mitogen-activated protein kinases and proliferation of endothelial cells. It is undergoing clinical trial investigation for the treatment of renal cell carcinomas. An oral quinoline urea derivative, tivozanib suppresses angiogenesis by being selectively inhibitory against vascular endothelial growth factor.  [1][2]
 
Reference:
[1] IDrugs 2010, 13, 636-645.
[2] J Neurosic. 2010, 30, 6743-6750.
 
 
Chemical Information
Molecular Weight (WM):
454.86
Formula:
C22H19ClN4O5
CAS No:
475108-18-0
Purity:
≥ 98%
Synonyms:
KRN951, KRN 951, AV 951
 
DMSO ≥ 39 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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