Apoptosis
Btk
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Product name : Afatinib (BIBW 2992)
Item : cc109
Price : 5g, $650;10g, $1050; 20g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 850140-72-6
Molecular Weight : 485.94
Formula : C₂₄H₂₅ClFN₅O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFR L858R , EGFR L858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM, 14 nM, respectively. BIBW-2992 irreversibly binds to and inhibits human epidermal growth factor receptors 1 and 2 (EGFR-1; HER2), which may result in the inhibition of tumor growth and angiogenesis. EGFR/HER2 are RTKs that belong to the EGFR superfamily; both play major roles in tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types. [1][2]
Reference:
[1] Curr. Opin. Investig. Drugs 2008, 9, 1336-1346.
[2] Oncogene 2008, 27, 4702-4711.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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