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Product name : Afatinib (BIBW 2992)
Item : cc109
Price : 10mg, $175; 50mg, $495; 100mg, $645; 200mg, $995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFR L858R , EGFR L858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM, 14 nM, respectively. BIBW-2992 irreversibly binds to and inhibits human epidermal growth factor receptors 1 and 2 (EGFR-1; HER2), which may result in the inhibition of tumor growth and angiogenesis. EGFR/HER2 are RTKs that belong to the EGFR superfamily; both play major roles in tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types.   [1][2]
 
Reference:
[1] Curr. Opin. Investig. Drugs 2008, 9, 1336-1346.
[2] Oncogene 2008, 27, 4702-4711.
 
 
Chemical Information
Molecular Weight (WM):
485.94
Formula:
C24H25ClFN5O5
CAS No:
439081-18-2, 936631-70-8 (Maleic acid), 1254955-21-9 (XHCl)
Purity:
≥ 98%
Synonyms:
BIBW 2992
 
DMSO ≥ 97 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 97 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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