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Product name : Varlitinib (ARRY 334543)
Item : cc760
Price : 200mg, $1250;500mg, $2090; 1g, $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
CAS : 845272-21-1
Molecular Weight : 466.94
Formula : C₂₂H₁₉ClN₆O₂S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Varlitinib (ARRY-334543) is a selective and potent ErbB1 and ErbB2 inhibitor with IC50 of 7 nM and 2 nM, respectively. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone. [1]
 
Reference:
[1] U.S. Pat. Appl. Publ., 20050043334, 24 Feb 2005.
 
Chemical Information
Molecular Weight (WM):
466.94
Formula:
C22H19ClN6O2S
CAS No:
845272-21-1,1146629-86-8 (toslyate)
Purity:
≥ 98%
Synonyms:
ARRY334543
 
DMSO ≥ 6 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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