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Product name : PD 153035
Item : cc538
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 153436-54-5
Molecular Weight : 360.21
Formula : C₁₆H₁₄BrN₃O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
PD-153035 is an extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). PD153035 rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. PD 153035 also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. [1][2]
 
Reference:
[1] Invest. New Drugs 1996, 13, 295-302.
[2] Science 1994, 265, 1093-1095.
 
 
Chemical Information
Molecular Weight (WM):
396.67
Formula:
C16H14BrN3O2·HCl
CAS No:
153436-54-5, 183322-45-4 (HCl)
Purity:
≥ 98%
Synonyms:
PD 153035
 
DMSO < 1 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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