Apoptosis
Btk
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Product name : NVP-TAE684 (TAE684)
Item : cc17
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 761439-42-3
Molecular Weight : 614.2
Formula : C₃₀H₄₀ClN₇O₃S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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TAE684 (NVP-TAE684) is a highly potent and selective smallmolecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM. NVP-TAE684 treatment resulted in a rapid and sustained inhibition of phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest. In vivo, TAE-684 suppressed lymphomagenesis in two independent models of ALK-positive ALCL and induced regression of established Karpas-299 lymphomas. TAE 684 also induced down-regulation of CD30 expression, suggesting that CD30 may be used as a biomarker of therapeutic NPM-ALK kinase activity inhibition. [1][2]
Reference:
[1] Proc. Natl. Acad. Sci. USA 2007, 104, 2025.
[2] Biochem. J 2011, 440, 405-413.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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