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Products > Receptor Tyrosine Kinase > ALK > NVP-TAE684 (TAE684)
Product name : NVP-TAE684 (TAE684)
Item : cc17
Price : 10mg, $195; 50mg, $675; 100mg, $965; 200mg, $1655
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
TAE684 (NVP-TAE684) is a highly potent and selective smallmolecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM.  NVP-TAE684 treatment resulted in a rapid and sustained inhibition of phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest. In vivo, TAE-684 suppressed lymphomagenesis in two independent models of ALK-positive ALCL and induced regression of established Karpas-299 lymphomas. TAE 684 also induced down-regulation of CD30 expression, suggesting that CD30 may be used as a biomarker of therapeutic NPM-ALK kinase activity inhibition. [1][2]
 
Reference:
[1] Proc. Natl. Acad. Sci. USA 2007, 104, 2025.
[2] Biochem. J 2011, 440, 405-413.
 
 
Chemical Information
Molecular Weight (WM):
614.20
Formula:
C30H40ClN7O3S
CAS No:
761439-42-3
Purity:
≥ 98%
Synonyms:
TAE684
 
DMSO ≥ 30 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 2 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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