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Products > Protease > HSP > Tanespimycin (17-AAG, NSC330507)
Product name : Tanespimycin (17-AAG, NSC330507)
Item : cc545
Price : 10mg, $55; 50mg, $155; 100mg, $295; 200mg, $495
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
17-AAG (Tanespimycin) is a potent heat shock protein 90 (Hsp90) inhibitor with IC50 of 5 nM.Tanespimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells.  [1][2]
 
Reference:
[1] Nature 2003, 425, 407-410.
[2] Clin. Cancer Res. 2002, 8, 986-993.
 
 
Chemical Information
Molecular Weight (WM):
585.69
Formula:
C31H43N3O8
CAS No:
75747-14-7, 911710-03-7 (HCl)
Purity:
≥ 98%
Synonyms:
NSC 330507, CP 127374, CP-127374
 
DMSO ≥ 20 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 5 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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