Product name : Tanespimycin (17-AAG, NSC330507)
Item : cc545
Price : 1g, $650;2g, $1050; 5g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 75747-14-7
Molecular Weight : 585.69
Formula : C₃₁H₄₃N₃O₈
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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17-AAG (Tanespimycin) is a potent heat shock protein 90 (Hsp90) inhibitor with IC50 of 5 nM.Tanespimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells. [1][2]
Reference:
[1] Nature 2003, 425, 407-410.
[2] Clin. Cancer Res. 2002, 8, 986-993.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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