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Product name : BIIB 021(CNF 2004)
Item : cc544
Price : 10mg, $165; 50mg, $675; 100mg, $1175; 200mg, $1995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
BIIB021 (CNF2024) ,is a novel fully synthetic inhibitor of Hsp90. It binds competitively with geldanamycin in the ATP-binding pocket of Hsp90 (Ki=1.7nM). BIIB-021 specifically blocks active HSP90, inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; this may result in the inhibition of cellular proliferation in susceptible tumor cell populations. HSP90, a chaperone protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins. [1][2]
 
Reference:
[1] J Med. Chem. 2007, 50, 2767-2778.
[2] Mol. Cancer Ther. 2009, 8, 921-929.
 
 
Chemical Information
Molecular Weight (WM):
318.76
Formula:
C14H15ClN6O
CAS No:
848695-25-0, 848696-06-0 (XHCl), 848696-07-1 (methanesulfonate)
Purity:
≥ 98%
Synonyms:
CNF 2024, CNF-2024, BIIB 021
 
DMSO ≥ 64 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 2 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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