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Product name : Ganetespib (STA 9090)
Item : cc751
Price : 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
contact : Send inquiry to: info@acesobio.com
CAS : 888216-25-9
Molecular Weight : 364.4
Formula : C₂₀H₂₀N₄O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Ganetespib (STA-9090) is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells. Ganetespib binds to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional HsP90 for maintenance. Hsp90, a 90 kDa molecular chaperone upregulated in a variety of tumor cells, plays a key role in the conformational maturation, stability and function of "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used as a surrogate marker for Hsp90 inhibition. [1][2]
 
Reference:
[1] Int. J Cancer 2009, 125, 2792-2801.
[2] Mol. Cancer Ther. 2012, 11, 1466-1476.
 
Chemical Information
Molecular Weight (WM):
364.40
Formula:
C20H20N4O3
CAS No:
888216-25-9, 1143571-94-1
Purity:
≥ 98%
Synonyms:
STA9090
 
DMSO ≥ 40 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 9 mg/mL
 
2 years    -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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