Favorite  |  Set Home
Products > Protease > HSP > SNX 2112
Product name : SNX 2112
Item : cc397
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 908112-43-6
Molecular Weight : 464.48
Formula : C₂₃H₂₇F₃N₄O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
SNX-2112 selectively binds to the ATP pocket of Hsp90 family members Hsp90α and Hsp90β with Ka of 30 nM and 30 nM, respectively. In all cell lines, SNX2112 led to degradation of MET, HER-2, EGFR, and AKT as well as abrogation of Ras/Raf/MEK/MAPK and PI3K/AKT signaling, followed by complete cell cycle arrest.  [1][2]
 
Reference:
[1] Biosci. Biotechnol. Biochem. 2011, 75, 1540-1545.
[2] Biomed. Pharmacother. 2011, 65, 132-136.
 
 
Chemical Information
Molecular Weight (WM):
464.48
Formula:
C23H27F3N4O3
CAS No:
908112-43-6, 945626-71-1
Purity:
≥ 98%
Synonyms:
SNX 2112
 
DMSO ≥ 93 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 2 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

Related Products :
PF 04929113 (SNX 5422)
PF 04929113 (SNX 5422)
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
KW 2478
KW 2478
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
NVP-BEP800 (VER 82576)
NVP-BEP800 (VER 82576)
Price: 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
MPC 3100
MPC 3100
Price: 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
Geldanamycin
Geldanamycin
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
Ganetespib (STA 9090)
Ganetespib (STA 9090)
Price: 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
BIIB 021(CNF 2004)
BIIB 021(CNF 2004)
Price: 10mg, $165; 50mg, $675; 100mg, $1175; 200mg, $1995
Tanespimycin (17-AAG, NSC330507)
Tanespimycin (17-AAG, NSC330507)
Price: 1g, $650;2g, $1050; 5g $1650