Apoptosis
DPP4
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Product name : MG 132
Item : cc245
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 133407-82-6
Molecular Weight : 475.62
Formula : C₂₆H₄₁N₃O₅
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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MG132 (carbobenzoxyl-leucyl-leucyl-leucinal, ZLLLal) is potent inhibitor of proteasome with IC50 of 100 nM. MG 132 potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. [1][2]
Reference:
[1] J Biol. Chem. 1996, 119, 572-576.
[2] Cancer Res. 1999, 59, 5586-5595.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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