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Product name : Oprozomib (ONX 0912)
Item : cc798
Price : 10mg, $375; 50mg, $895; 100mg, $1295;200mg, $1995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Oprozomib(ONX-0912) is an orally bioavailable proteasome inhibitor with potential antineoplastic activity. ONX0912 inhibits the activity of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome; this may result in an accumulation of unwanted or misfolded proteins. Disruption of various cell signaling pathways may follow, eventually leading to the induction of apoptosis and inhibition of tumor growth. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated. [1][2]
 
Reference:
[1] Leukemia 2013, 27, 430-440.
[2] Clin. Cancer Res. 2012, 18, 5639-5649.
 
Chemical Information
Molecular Weight (WM):
532.61
Formula:
C25H32N4O7S
CAS No:
935888-69-0
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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