Product name : ONX 0914 (PR 957)
Item : cc799
Price : 200mg, $1250;500mg, $2090; 1g, $2995;
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
CAS : 960374-59-8
Molecular Weight : 580.67
Formula : C₃₁H₄₀N₄O₇
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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ONX-0914 (PR-957) is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. Recent evidence suggests that the immunoproteasome regulates the production of several inflammatory cytokines, including Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), IL-17, and IL-23. In preclinical models of rhematoid arthritis and lupus, ONX0914 blocked progression of these diseases at well-tolerated doses. [1][2]
Reference:
[1] J Immunol. 2011, 187, 5548-5557.
[2] J Biol. Chem. 2010, 285, 40125-4-134.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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