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Product name : ONX 0914 (PR 957)
Item : cc799
Price : 10mg, $475; 50mg, $1795; 100mg, $2795;200mg, $3795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
ONX-0914 (PR-957) is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. Recent evidence suggests that the immunoproteasome regulates the production of several inflammatory cytokines, including Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), IL-17, and IL-23. In preclinical models of rhematoid arthritis and lupus, ONX0914 blocked progression of these diseases at well-tolerated doses. [1][2]
 
Reference:
[1] J Immunol. 2011, 187, 5548-5557.
[2] J Biol. Chem. 2010, 285, 40125-4-134.
 
Chemical Information
Molecular Weight (WM):
580.67
Formula:
C31H40N4O7
CAS No:
960374-59-8
Purity:
≥ 98%
Synonyms:
PR957
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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