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Products > Protease > Proteasome > Bortezomib (PS 341, MG 341)
Product name : Bortezomib (PS 341, MG 341)
Item : cc75
Price : 10mg, $95, 50mg, $495, 100mg, $795; 200mg, $1175
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Bortezomib (PS-341, Velcade) is a potent proteasome inhibitor with Ki of 0.6 nM. The boron atom in bortezomib binds the catalytic site of the 26S proteasome with high affinity and specificity. In normal cells, the proteasome regulates protein expression and function by degradation of ubiquitylated proteins, and also cleanses the cell of abnormal or misfolded proteins. proteasome inhibition may prevent degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon suppression of pro-apoptotic pathways.  [1][2]
 
Reference:
[1] Leukemia 2007, 21, 838-842.
[2] Clin. Cancer Res. 2003, 9, 6316-6325.
 
 
Chemical Information
Molecular Weight (WM):
384.24
Formula:
C19H25BN4O4
CAS No:
179324-69-7
Purity:
≥ 98%
Synonyms:
MG341, PS341
 
DMSO ≥ 77 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 77 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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