Product name : Geldanamycin
Item : cc573
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 30562-34-6
Molecular Weight : 560.64
Formula : C₂₉H₄₀N₂O₉
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Geldanamycin is a natural existing Hsp90 inhibitor with Kd with 1.2 μM or 0.78 μM while binding to full-length dimeric Hsp90 or the N-terminal domain Hsp90. Geldanamycin binds in the ATP-binding site in the N-terminus domain of Hsp90s (residues 1-220). Geldanamycin inhibits the ATPase activity of Hsp90 in a dose-dependent manner. Geldanamycin is a typical anti-tumor reagent, shows a mean GI50 with 0.18 μM against the panel of 60 human tumor cell lines. [1][2]
Reference:
[1] J Med. Chem. 1999, 42, 260-266.
[2] Cancer Chemother. Pharmacol. 1995, 36, 305-315.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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