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Products > Receptor Tyrosine Kinase > IGF-1R > AG 1024 (Tyrphostin)
Product name : AG 1024 (Tyrphostin)
Item : cc273
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 65678-07-1
Molecular Weight : 305.17
Formula : C₁₄H₁₃BrN₂O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
AG-1024 (Tyrphostin) is a specific IGF-1R/IR inhibitor with IC50 of 0.4 μM and 0.1 μM, respectively. Human breast cancer cell studies report AG1024 to induce apoptosis, inhibit cell proliferation, decrease bcl-2 and phospho-Akt1 expression, and elevate the expression levels of Bax, p53 and p21. Studies report AG 1024 to block tyrosine kinase activity and to have a lower IC50 for IGF-1 in comparison to insulin receptors. Other studies indicate that exposure of SHR cells to AG 1024 decreases Ang II-mediated NAD(P)H oxidase activation. [1][2]
 
Reference:
[1] Endocrinology 1997, 138, 1427-1433.
[2] Br. J Cancer 2001, 85, 2017-2021.
 
 
Chemical Information
Molecular Weight (WM):
305.17
Formula:
C14H13BrN2O
CAS No:
65678-07-1
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 61 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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