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Product name : BI 6727 (Volasertib)
Item : cc629
Price : 10mg, $125; 50mg, $495; 100mg, $795; 200mg, $1095
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
BI6727 (Volasertib) is a highly potent Polo-like kinase 1 (Plk1) inhibitor with IC50 of 0.87 nM.PLK1 proteins are found in the nuclei of all dividing cells and control multiple stages of the cell cycle and cell division. Raised levels of PLK1 increase the probability of improper segregation of chromosomes which is a critical stage in the development of many cancers. Raised levels of PLK1 have been associated with a poorer prognosis and overall survival in some cancers.   [1][2]
 
Reference:
[1] Clin. Cancer Res. 2009, 15, 3094-3102.
[2] Cancer Res. 2011, 71, 1385-1395.
 
  
Chemical Information
Molecular Weight (WM):
618.81
Formula:
C34H50N8O3
CAS No:
755038-65-4, 946161-17-7 (3HCl)
Purity:
≥ 98%
Synonyms:
BI-6727
 
DMSO ≥ 23 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 124 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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