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Products > Receptor Tyrosine Kinase > c-Met > Golvatinib (E 7050)
Product name : Golvatinib (E 7050)
Item : cc 653
Price : 10mg, $275; 50mg, $795; 100mg, $1295; 200mg, $2095
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Golvatinib (also known as E7050) is [1][2]an orally bioavailable dual kinase inhibitor of c-Met and VEGFR-2 tyrosine kinases with potential antineoplastic activity. E-7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of various tumor cell types and play important roles in tumor cell growth, migration and angiogenesis. [1][2]
 
Reference:
[1] Cancer Sci. 2010, 101, 210-215.
[2] Clin. Cancer Res. 2012, 18, 1663-1671.
 
Chemical Information
Molecular Weight (WM):
633.69
Formula:
C33H37F2N7O4
CAS No:
928037-13-2 , 1007601-96-8 (L(+)-Tartaric Acid), 1007601-91-3 (Fumaric acid)
Purity:
≥ 98%
Synonyms:
E 7050
 
DMSO ≥ 72 mg/mL
Solubility (25℃)
Water ≥ 72 mg/mL
 
Ethanol ≥ 12 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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