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Products > Receptor Tyrosine Kinase > c-Met > Foretinib (GSK 1363089, XL 880)
Product name : Foretinib (GSK 1363089, XL 880)
Item : cc541
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 849217-64-7
Molecular Weight : 632.65
Formula : C₃₄H₃₄F₂N₄O₆
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Foretinib (GSK1363089, XL880) is a novel MET and VEGFR2/KDR kinases inhibitor with an IC50 of 0.4 and 0.8 nM for MET and KDR, respectively. GSK-1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers. VEGFR2 is found on endothelial and hematopoietic cells and mediates the development of the vasculature and hematopoietic cells through VEGF signaling.   [1][2]
 
Reference:
[1] Cancer Res. 2009, 69, 6871-6878.
[2] Cancer Res. 2009, 69, 8009-8016.
 
 
Chemical Information
Molecular Weight (WM):
632.65
Formula:
C34H34F2N4O6
CAS No:
849217-64-7
Purity:
≥ 98%
Synonyms:
XL-880, XL880, XL 880
 
DMSO ≥ 127 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 12 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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