Apoptosis
Btk
|
Product name : Foretinib (GSK 1363089, XL 880)
Item : cc541
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 849217-64-7
Molecular Weight : 632.65
Formula : C₃₄H₃₄F₂N₄O₆
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 |
| Details: | |||||||||||||||||||||||||
Foretinib (GSK1363089, XL880) is a novel MET and VEGFR2/KDR kinases inhibitor with an IC50 of 0.4 and 0.8 nM for MET and KDR, respectively. GSK-1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers. VEGFR2 is found on endothelial and hematopoietic cells and mediates the development of the vasculature and hematopoietic cells through VEGF signaling. [1][2]
Reference:
[1] Cancer Res. 2009, 69, 6871-6878.
[2] Cancer Res. 2009, 69, 8009-8016.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
|
| Related Products : |
|
|
|
|
||||||||
|
|
|
|
Chinese
Deutsch
Espanol
Francais
Italiano
Portugues
Japanese
Korean
Arabic
Russian