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Product name : OC 000459
Item : cc 659
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 851723-84-7
Molecular Weight : 348.37
Formula : C₂₁H₁₇FN₂O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
OC000459, is a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. OC-000459 potently displaces [³H]PGD₂ from human recombinant DP₂ (K(i) = 0.013 μM), rat recombinant DP₂ (K(i) = 0.003 μM), and human native DP₂ (Th2 cell membranes; K(i) = 0.004 μM) but does not interfere with the ligand binding properties or functional activities of other prostanoid receptors (prostaglandin E₁₋₄ receptors, D prostanoid receptor 1, thromboxane receptor, prostacyclin receptor, and prostaglandin F receptor). [1][2]
 
Reference:
[1] Clin. Exp. Allergy 2012, 42, 38-48.
[2] J Pharmacol. Exp. Ther. 2012, 340, 473-482.
 
 
Chemical Information
Molecular Weight (WM):
348.37
Formula:
C21H17FN2O2
CAS No:
851723-84-7
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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