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ADL 5859
ADL5859 is an δ-opioid receptor agonist (Ki=0.84 nM, EC50=20 nM). Preclinical work suggests that δ-specific agonists may exhibit superior ...
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ADX 47273
ADX47273 is a potent and specific mGlu5 receptor antagonist with IC50 of 0.17μM. ADX-47273 has nootropic and antipsychotic effects in animal studie...
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Nebivolol (R 67145)
Nebivolol has selective β1 receptor blocking activity with an IC50 value of 0.8 nM in a rabbit lung β1-adrenoceptor binding assay. Nebivolol...
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Bosentan
Bosentan is a competitive antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors. Under normal conditions, endothelin...
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Indacaterol
Indacaterol is a novel beta2-adrenoceptor agonist in development for the once-daily treatment of asthma and chronic obstructive pulmonary disease. &nb...
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Naxagolide
Naxagolide is a dopamine D2-receptor agonist which is used for the treatment of extrapyramidal disorders. This compound is an antiparkinsonian drug. [...
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Tasosartan
Tasosartan, is a new, long-acting, nonpeptide angiotensin II receptor antagonist. Angiotensin II receptor antagonists are selective blockers of the re...
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JTC 801
JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM. JTC 801 inhibited the binding of [(3)H]-nociceptin to huma...
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SYN 115
SYN-115 (Tozadenatn) is an adenosine A2a receptor antagonist. Adenosine A(2a) receptor antagonists reduce symptom severity in Parkinson disease (PD) a...
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LDE 225 (Erismodegib)
LDE225 (NVP-LDE225, Erismodegib) is a novel and specific, orally bioavailable Smo inhibitor with an IC50 of 11 nM. Smo antagonist NVP-LDE225 inhibits ...
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Ciproxifan (FUB 359)
Ciproxifan (FUB-359), Antagonists of H3-type histamine receptors exhibit cognitive-enhancing properties in various memory paradigms as well as evidenc...
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Istradefylline (KW 6002)
Istradefylline (KW-6002) is a selective adenosine A2A receptor (A2AR) antagonist with Ki of 2.2 nM.The novel adenosine A2A receptor antagonist KW-6002...
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Pramipexole
Pramipexole (Mirapex, Mirapexin, Sifrol) is a dopamine agonist of the non-ergoline class indicated for treating early-stage Parkinson's disease (PD) a...
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Azilsartan (TAK 536)
Azilsartan medoxomil (TAK-536) lowers blood pressure by blocking the action of angiotensin II, a vasopressor hormone. [1][2]
Reference:
[1] ...
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Apoptosis
Sigma Receptor
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