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SB 408124
SB-408124 is a non-peptide antagonist for OX1 with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively. Calcium mobilization studies s...
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GW 842166X
GW842166X is a potent and highly selective agonist of CB2 receptor. The peripheral cannabinoid (CB2) receptor is a G protein-coupled receptor (GPCR) t...
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VU 0361737
VU-0361737 is a selective positive allosteric modulator for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively. [1...
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CGS 21680
CGS-21680 is an A2A adenosine receptor agonist (Ki = 27 nM). CGS21680 has affinity for A1 and A3 adenosine receptors but can be used to distinguish A2...
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PF 5274857
PF-5274857 is a potent and selective Smoothened (Smo) antagonist with IC50 and Ki of 5.8 nM and 4.6 nM, respectively. Inhibition of the Smoothened (Sm...
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Purmorphamine
Purmorphamine directly binds and activates Smoothened with IC50 of ~ 1.5 μM in compete with Smo antagonist and also is a inducer of osteoblast diff...
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JNJ 7777120
JNJ-7777120 is a potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM. JNJ7777120 Ki values for the histamine H1...
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ARN 509
ARN-509 is an androgen receptor (AR) antagonist with IC50 of 16 nM. ARN509 binds to AR in target tissues thereby preventing androgen-induced receptor ...
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Otenabant (Synonyms: CP-945598)
CP-945598 HCl is a high affinity and selective cannabinoid type 1 receptor antagonist with Ki of 0.7 nM. CP945598 displays low affinity for CB2 recept...
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Zibotentan (ZD 4054)
Zibotentan (ZD4054) is a specific Endothelin A receptor (ETA) antagonist with IC50 of 21 nM. Zibotentan (ZD-4054) binds selectively to the ET-A recept...
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sitaxsentan(TBC 11251)
Sitaxentan (TBC-11251) is a small molecule that blocks the action of endothelin (ET) on the endothelin-A (ETA) receptor selectively (by a factor of 60...
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Ambrisentan
Ambrisentan functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA). [1][2]
Reference...
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NPS 2143
NPS-2143 is a novel potent and selective antagonist of Ca(2+) receptor with IC50 of 43 nM in HEK 293 cells. NPS2143 blocks increases in cytoplasmic Ca...
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Eprosartan
Eprosartan is an angiotensin II receptor antagonist used for the treatment of high blood pressure. [1]
Reference:
[1] Blood Press. 2001, 10,...
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Apoptosis
Sigma Receptor
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