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Product name : PIK 93
Item : cc491
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 593960-11-3
Molecular Weight : 389.88
Formula : C₁₄H₁₆ClN₃O₄S₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
PIK-93 is a PI4KIIIβ inhibitor (IC50 at 19 nM). PIK-93 is the first reported PI4-kinase inhibitor, which is able to inhibit PI4KIIIβ at low-nanomolar range. In addition, PIK-93 also inhibits potently PI3Kγ in vitro (IC50 at 16 nM). PIK-93 inhibits p110α, p110β, p110δwith IC50 of 0.039, 0.59, 0.12 µM. PIK-93 also displays the typical hydrogen bonding to the backbone amide of Val882, and additional ones to the backbone carbonyl of Val882 and between its sulphonamide and Asp964. [1][2]
 
Reference:
[1] Biochimica. Et Biophysica. Acta. 2008, 1784, 159-185.
[2] J Biol. Chem. 2012, 287, 17672-17681.
 
 
Chemical Information
Molecular Weight (WM):
389.88
Formula:
C14H16ClN3O4S2
CAS No:
593960-11-3
Purity:
≥ 98%
Synonyms:
PKI 93, PKI93
 
DMSO ≥ 78 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 2 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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