Product name : PIK 93
Item : cc491
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 593960-11-3
Molecular Weight : 389.88
Formula : C₁₄H₁₆ClN₃O₄S₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
|
Details: | |||||||||||||||||||||||||
PIK-93 is a PI4KIIIβ inhibitor (IC50 at 19 nM). PIK-93 is the first reported PI4-kinase inhibitor, which is able to inhibit PI4KIIIβ at low-nanomolar range. In addition, PIK-93 also inhibits potently PI3Kγ in vitro (IC50 at 16 nM). PIK-93 inhibits p110α, p110β, p110δwith IC50 of 0.039, 0.59, 0.12 µM. PIK-93 also displays the typical hydrogen bonding to the backbone amide of Val882, and additional ones to the backbone carbonyl of Val882 and between its sulphonamide and Asp964. [1][2]
Reference:
[1] Biochimica. Et Biophysica. Acta. 2008, 1784, 159-185.
[2] J Biol. Chem. 2012, 287, 17672-17681.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
|
Related Products : |
|
|
|
|
||||||||
|
|
|
|