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Product name : INCB 28060
Item : cc219
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1029712-80-8
Molecular Weight : 412.42
Formula : C₂₃H₁₇FN₆O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
INCB-28060 is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.  [1]
 
Reference:
[1] Clin. Cancer Res. 2011, 17, 7127-7138.
 
 
Chemical Information
Molecular Weight (WM):
412.42
Formula:
C23H17FN6O
CAS No:
1029712-80-8, 1029714-89-3 (XHCl), 1197376-85-4 (2HCl)
Purity:
≥ 98%
Synonyms:
INCB 28060
 
DMSO ≥ 10 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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