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Products > Receptor Tyrosine Kinase > EGFR > AG 1478 (Tyrphostin AG-1478, NSC 693255)
Product name : AG 1478 (Tyrphostin AG-1478, NSC 693255)
Item : cc598
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 153436-53-4
Molecular Weight : 315.75
Formula : C₁₆H₁₄ClN₃O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
AG-1478 (Tyrphostin AG-1478, NSC-693255) is a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with IC50 of 3 nM. AG1478 (NSC693255) reversibly inhibits rat brain Kv1.5 potassium channels (IC50 = 9.8 µM) independent of PTK activity. AG 1478 (NSC 693255) also inhibits the growth of leiomyoma and myometrium cell cultures with IC50 values of 5.6 and 5.7 µM, respectively. This inhibitor suppresses MAP kinase activation and strongly inhibits induction of fos gene expression and DNA synthesis.   [1][2]
 
Reference:
[1] Cancer Res. 1996, 56, 3859-3861.
[2] Proc. Natl. Acad. Sci. USA 2003, 100, 15871-15876.
 
 
Chemical Information
Molecular Weight (WM):
315.75
Formula:
C16H14ClN3O2
CAS No:
153436-53-4, 170449-18-0 (HCl)
Purity:
≥ 98%
Synonyms:
Tyrphostin AG1478
 
DMSO ≥ 63 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 13 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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