Apoptosis
MNK
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Product name : Doramapimod (BIRB 796)
Item : cc-440
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 285983-48-4
Molecular Weight : 527.66
Formula : C₃₁H₃₇N₅O₃
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1. Doramapimod is a highly potent inhibitor of p38 MAPK with a Kd value of 0.1 μM that blocks TNFα release in LPS-stimulated THP.1 cells with an IC50 value of 18 nM. At 10 μM, doramapimod inhibits JNK2α2 in vitro, but at the low concentration necessary to inhibit p38 MAPK, it does not affect the phosphorylation of JNK substrates in cells.[1][2]
Reference:
[1] Br. J Haematol. 2007, 136, 414-423.
[2] Bioorg. Med. Chem. Lett. 2003, 13, 3101-3104.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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