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Product name : PH 797804
Item : cc53
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 586379-66-0
Molecular Weight : 477.3
Formula : C₂₂H₁₉BrF₂N₂O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
PH-797804 is an ATP-competitive, readily reversible inhibitor of the α isoform of human p38 MAP kinase, exhibiting a Ki = 5.8 nM. PH797804 blocks inflammation-induced production of cytokines and proinflammatory mediators, such as prostaglandin E(2), at concentrations that parallel inhibition of cell-associated p38 MAP kinase. Furthermore, PH-797804 demonstrates robust anti-inflammatory activity in chronic disease models, significantly reducing both joint inflammation and associated bone loss in streptococcal cell wall-induced arthritis in rats and mouse collagen-induced arthritis. Finally, PH 797804 reduced tumor necrosis factor-alpha and interleukin-6 production in clinical studies. [1][2]
 
Reference:
[1] J Pharmacol. Exp. Ther. 2009, 331, 882-895.
[2] Biochemistry 2009, 48, 6402-6411.
 

Chemical Information
Molecular Weight (WM):
477.30
Formula:
C22H19BrF2N2O3
CAS No:
586379-66-0
Purity:
≥ 98%
Synonyms:
PH 797804
 
DMSO ≥ 96 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 10 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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