Apoptosis
MNK
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Product name : VX 745
Item : cc-466
Price : 200mg, $850;500mg, $1650; 1g $2250; 2g, $3450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 209410-46-8
Molecular Weight : 436.26
Formula : C₁₉H₉Cl₂F₂N₃OS
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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VX-745 is highly potent and selective p38α inhibitor (IC50 = 10 nM). VX-745 also blocks TNFα production in LPS-stimulated HWB in vitro (IC50 = 177 nM). VX-745 displays 1000-fold selectivity over closely related kinases, including ERK1, MK2 and JNK1-3. VX-745 is a lead anti-inflammatory candidate, p38 MAPK inhibitor (IC50=10 nM) for the treatment of Rheumatoid arthritis (RA).[1][2]
Reference:
[1] Blood 2003, 101, 703-705.
[2] Bioorg. Med. Chem. Lett. 2007, 17, 5107-5110.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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