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Product name : EX 527
Item : cc 651
Price : 10mg, $125; 50mg, $495; 100mg, $695; 200mg, $1095
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Mammalian sirtuin 1 (SIR1) is a dinucleotide-dependent histone deacetylase (HDAC) with roles in energy metabolism and inflammation. EX 527 is a cell-permeable, selective inhibitor of SIRT1 with IC50 of 98 nM. EX-527 inhibits other SIRTs only at much higher concentrations and has noe effect on other HDACs. [1][2]
 
Reference:
[1] J Med. Chem. 2005, 48, 8045-8054.
[2] Mol. Cell Biol. 2006, 26, 28-38.
 
 
Chemical Information
Molecular Weight (WM):
248.71
Formula:
C13H13ClN2O
CAS No:
848193-68-0
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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