Apoptosis
DHFR
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Product name : Rocilinostat (ACY 1215)
Item : cc 661
Price : 250mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1316214-52-4
Molecular Weight : 433.5
Formula : C₂₄H₂₇N₅O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Rocilinostat, also known as ACY1215, is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation. This leads to an accumulation of unfolded and misfolded ubiquitinated proteins and may eventually induce cancer cell apoptosis, and inhibition of cancer cell growth. HDAC6, a class II HDAC deacetylase located in the cytoplasm, appears to play a key role in the formation and activation of the aggresomes needed for degradation of misfolded proteins. Compared to non-selective HDAC inhibitor, ACY 1215 is able to reduce the toxic effects on normal, healthy cells. [1][2]
Reference:
[1] Bioorg. Med. Chem. Lett. 2011, 21, 471-474.
[2] ACS Med. Chem. Lett. 2010, 1, 204-208.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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