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Product name : Tubastatin A hydrochloride
Item : cc256
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS :  1310693-92-5
Molecular Weight :  371.86
Formula : C₂₀H₂₂ClN₃O₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
Tubastatin A is a potent and selective HDAC6 inhibitor. Demonstrates 1093-fold selectivity over HDAC1 (IC50 values of 15 nM for HDAC6 vs 16.4 µM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8, where it displayed 54-fold selectivity. This compound displayed dose-dependent protection against HCA induced neuronal cell death starting at 5 µM with near complete protection at 10 µM. [1][2]
 
Reference:
[1] J Am. Chem. Soc. 2010, 132, 10842-10846.
[2] Nature Medicine 2011, 17, 968-974.
 
 
Chemical Information
Molecular Weight (WM):
371.86
Formula:
C20H21N3O2·HCl
CAS No:
1310693-92-5
Purity:
≥ 98%
Synonyms:
Tubastatin A HCl
 
DMSO ≥ 8 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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