Product name : Tubastatin A hydrochloride
Item : cc256
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1310693-92-5
Molecular Weight : 371.86
Formula : C₂₀H₂₂ClN₃O₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Tubastatin A is a potent and selective HDAC6 inhibitor. Demonstrates 1093-fold selectivity over HDAC1 (IC50 values of 15 nM for HDAC6 vs 16.4 µM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8, where it displayed 54-fold selectivity. This compound displayed dose-dependent protection against HCA induced neuronal cell death starting at 5 µM with near complete protection at 10 µM. [1][2]
Reference:
[1] J Am. Chem. Soc. 2010, 132, 10842-10846.
[2] Nature Medicine 2011, 17, 968-974.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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