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Product name : CZC24832
Item : CR1939
Price : 100mg, $695; 200mg, $1195;
contact : Send inquiry to: info@acesobio.com
Additional Information :  We offer significant discount for bulky quantity order,Please ask price and availability of other quantities
CAS : 1159824-67-5
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Details:
 

Chemical Information

M.Wt 364.4 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C15H17FN6O2S
CAS No 1159824-67-5
Solubility

DMSO



Biological Activity of CZC24832

 

CZC24832 is a selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay); exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins.
IC50 value: 1.0 uM
Target: PI 3Kγ

 

[1]. Bell K, Sunose M, Ellard K, Cansfield A, Taylor J, Miller W, Ramsden N, Bergamini G, Neubauer G. SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors. oorg Med Chem Lett. 2012 Aug 15;22(16):5257-63.http://www.ncbi.nlm.nih.gov/pubmed/22819766

[2]. Bergamini G, Bell K, Shimamura S, Werner T, Cansfield A, Müller K, Perrin J, Rau C, Ellard K, Hopf C, Doce C, Leggate D, Mangano R, Mathieson T, O'Mahony A, Plavec I, Rharbaoui F, Reinhard F, Savitski MM, Ramsden N, Hirsch E, Drewes G, Rausch O, Bantscheff M, Neubauer G. A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. Nat Chem Biol. 2012 Apr 29;8(6):576-82. doi: 10.1038/nchembio.957. 


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