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Product name : PD-173955
Item : CR1858
Price : 100mg, $945; 200mg, $1485
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CAS : 260415-63-2
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Details:
 Name:  PD-173955

CAS#: 260415-63-2

Chemical Formula: C21H16Cl2N4OS
Exact Mass: 442.04219
Molecular Weight: 443.34894
Elemental Analysis: C, 56.89; H, 3.64; Cl, 15.99; N, 12.64; O, 3.61; S, 7.23


Description of  PD-173955: PD-173955 is a src tyrosine kinase inhibitor. PD173955inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1).PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth. 



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