SNS 314

SNS 314 is an ATP-competitive, potent and selective inhibitor of Aurora kinases A (IC50 = 9.0 nM), Aurora kinase B (IC50 = 31 nM) and Aurora kinase C ...

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MLN 8237 (Alisertib)

MLN 8237 is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase...

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AT 9283

AT 9283 is a substance being studied in the treatment of some types of cancer. It is small molecule a multi-targeted c-ABL, JAK2, Aurora A and B inhib...

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CCT 129202

CCT129202 is a Aurora kinase inhibitor with IC50 of 0.042 ± 0.022, 0.198 ± 0.05, and 0.227 ± 0.064 μmol/L for Aurora A, Aurora...

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ENMD 2076

ENMD 2076 is an orally bioavailable multitargeted antiangiogenic and Aurora kinase inhibitor with IC50 of 3, 13, 350, 23, 40, 93 and 120 nM for Flt-3,...

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CYC 116

CYC 116 is an orally bioavailable small molecule multi-kinase inhibitor with antineoplastic activity. Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits ...

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AMG 900

AMG 900 is a small-molecule inhibitor of Pan-aurora kinases with an IC50 of median 3.5 nM. Aurora kinase inhibitor AMG 900 selectively binds to and in...

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SB 743921

SB 743921 is a second generation, highly potent and active KSP inhibitor with a Ki of 0.1 nM for KSP (Eg5). SB-743921 selectively inhibits kinesin spi...

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TAK 901

TAK 901 is a small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. Aurora B kinase inhibitor TAK-90...

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