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Product name : ENMD 2076
Item : cc-471
Price : 200mg, $945; 500mg, $1785
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 934353-76-1
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Details:
ENMD 2076 is an orally bioavailable multitargeted antiangiogenic and Aurora kinase inhibitor with IC50 of 3, 13, 350, 23, 40, 93 and 120 nM for Flt-3, AurA, AurB, Src, KDR/VEGFR2 and FEGR1. ENMD-2076 selectively binds to and inhibits non-specified tyrosine kinases and Aurora kinases (AKs). The inhibition of AKs may result in the inhibition of cell division and proliferation and may induce apoptosis in tumor cells that overexpress AKs; antiangiogenic activity is related to the inhibition of angiogenic tyrosine kinases. AKs are serine-threonine kinases that play an essential role in mitotic checkpoint control during mitosis and are important regulators of cell division and proliferation. [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2011, 10, 126-137.
[2] Clin. Caner Res. 2010, 16, 2989-2998.
 
 
Chemical Information
Molecular Weight (WM):
525.56
Formula:
C25H31N7O6
CAS No:
934353-76-1,1291074-87-7
Purity:
≥ 98%
Synonyms:
ENMD2076, ENMD-2076
 
DMSO ≥ 105 mg/mL
Solubility: (R.T.: 25℃):
Water ≥ 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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