Favorite  |  Set Home
Products > Aurora/Ksp > Aurora > MLN 8237 (Alisertib)
Product name : MLN 8237 (Alisertib)
Item : cc-313
Price : 200mg, $1350;500mg, $1950; 1g $2650; 2g, $3750
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1028486-01-2
Molecular Weight : 518.92
Formula : C₂₇H₂₀ClFN₄O₄
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
MLN 8237 is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with median IC50 of 61 nM. Alisertib binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers. [1][2]
 
Reference:
[1] Blood, 2010, 115, 5202-5213.
[2] Chem. Biol. 2010, 5, 563-576.
 
 Chemical Information
Molecular Weight (WM):
518.92
Formula:
C27H20ClFN4O4
CAS No:
1028486-01-2
Purity:
≥ 98%
Synonyms:
MLN-8237, MLN8237, Alisertib
 
DMSO ≥ 44 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

Related Products :
SNS 314
SNS 314
Price: 200mg, $750;500mg, $1350; 1g $1950; 2g, $3150
Hesperadin
Hesperadin
Price: 200mg, $750;500mg, $1350; 1g $1950; 2g, $3150
MK 5108 (VX 689)
MK 5108 (VX 689)
Price: 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
GSK 1070916
GSK 1070916
Price: 200mg, $1350;500mg, $1950; 1g $2650; 2g, $3750
MLN 8054
MLN 8054
Price: 200mg, $1250;500mg, $2350; 1g $2950; 2g, $3850
PHA 680632
PHA 680632
Price: 200mg, $1750;500mg, $2350; 1g $2950; 2g, $4150
VX 680
VX 680
Price: 1g $650; 2g, $1050
SCH 1473759
SCH 1473759
Price: 200mg, $1250;500mg, $2090; 1g, $2995; 2g, $4395